陈路，研究员，尊龙凯时华西第二尊龙凯时疾病基因转录剪切调控研究室主任，生物治疗国家重点实验室，博士生导师。剑桥大学（University of Cambridge）和桑格研究所（Wellcome Trust Sanger Institute）博士后（2011-2016），国家高层次青年计划入选者。承担国家优秀青年基金项目、国家重点研发计划“干细胞及转化研究”青年项目等各类课题9项。主要从事选择性剪接在造血干细胞分化、癌症发生和多层面组学等领域中的研究工作。在国外重要期刊发表SCI收录论文38篇，他引4500多次。申请发明专利4项，第一或通讯作者（包括共同）的身份共发表16篇论文，包括Science、Cell、Cell Host Microbe、Cell Research、STTT（2篇）和Nucleic Acids Research（2篇）等
研究方向：以生物信息、人工智能、单细胞和三代测序技术开发、生物学实验为手段，在干细胞分化、疾病发生等领域中开展研究工作，主要针对多组学在精准医学中的应用和疾病早期诊疗和药物靶点研究，从而揭示癌症、血液病、自身免疫性、感染性等疾病的发病机理，并希望疾病的诊断和治疗提供新的思路和方法。
学术任职：现任中国实验血液学会青年委员会副主委；中国生理学会血液生理学专业委员会委员；四川省预防医学会妇科肿瘤预防控制分会委员；2019年被批准为“第十三批四川省卫生健康委员会学术技术带头人”。
近年主持基金项目：
1、2017.07-2021.12/造血干细胞分化中的选择性剪切调控机制/国家重点研发计划/总经费576万元/项目负责人
2、2017.07-2021.12/神经干细胞命运决定的转录和转录后调控/国家重点研发计划/总经费584万元/项目骨干
3、2018.01-2020.12/白血病的剪切调控机制/国家优秀青年科学基金项目/总经费150万元/项目负责人
4、2016.10-2019.10/国家人才项目/总经费300万元/项目负责人
5、2018-2020/ 2018年四川省人才项目/总经费50万元/项目负责人
6、2018-2020/ 2018年蓉漂计划项目/总经费200万元/项目负责人
7、2021-2023/四川省重点研发项目/儿童血液肿瘤疾病精准诊断和分层治疗体系建设（21ZDYF1891）/总经费100万元/项目负责人
8、2020.1-2020.6/尊龙凯时新型冠状病毒应急项目/基于CRISPR/Cas13a技术和三代测序的2019-nCoV快速检测和精准医学分析(0082604151012)/20万元/项目负责人
9、2021.11-2022.10/突变株新冠病毒与新发未知病原体快速测序溯源及低成本、现场可视化快筛技术研究/四川省重点研发项目/10万元/总经费300万元/参与
代表论文
Corresponding (*) or first author (#) papers (IF is based on 2021)
1. Zhou R, Xiao X, He P, et al. Lin JW*, Cheng L*, Chen L*. 2022. SCAPE: a mixture model revealing single-cell polyadenylation diversity and cellular dynamics during cell differentiation and reprogramming. Nucleic Acids Res, gkac167 (IF =16.971)
2. Ding C, Yan X, Xu M, et al. Chen L*, Wang Y*. 2022. Short-read and long-read full-length transcriptome of mouse neural stem cells across neurodevelopmental stages. Sci Data. 9(1):69. (IF = 6.444)
3. Zhang L, Zhang,Y, et al. Chen L*, Li W*. 2022. Integrated Single-cell RNA Sequencing Analysis Reveals Distinct Cellular and Transcriptional Modules associated with survival in Lung Cancer. Signal Transduction and Targeted Therapy, 7(1):9. (IF = 18.187)
4. Zheng X, Zhang D, Xu M, et al. Lin JW*, Chen L*. 2021. Short-read and long-read RNA sequencing of mouse hematopoietic stem cells at bulk and single-cell levels. Sci Data, 8(1):309. (IF = 6.444)
5. Chen G#, Zhang Y#, et al. Chen L*, Lin JW*, Li K*. 2021. Differential immune responses in pregnant patients recovered from COVID-19. Signal Transduction and Targeted Therapy, 6(1):1-15. (IF = 18.187)
6. Lin JW*#, Tang C#, Wei HC#, et al. Li W*, Geng J*, Ying B*, Chen L*. 2021. Genomic monitoring of SARS-CoV-2 uncovers an Nsp1 deletion variant that modulates type I interferon response. Cell Host & Microbe, 29(3):489-502. (IF = 21.023)
7. Li Z#, Zhang Y#, Bush SJ#, Tang C, Chen L, Zhang D, Urrutia AO*, Lin JW*, Chen L*. 2021. MeDAS: a me-x-tazoan Developmental Alternative Splicing database. Nucleic Acids Research, 49(D1):D144-D150. (IF =16.971)
8. Wang X#, Zhou R#, Xiong Y, et al. Chen L*, Wang Y*. 2021. Sequential fate-switches in stem-like cells drive the tumorigenic trajectory from human neural stem cells to malignant glioma. Cell Research, 31(6):684-702. (IF = 25.617)
9. Yao Y, Yang J, Qin Q, Tang C, Li Z, Chen L*, Rao S*. 2020. Functional annotation of genetic associations by transcriptome-wide association analysis provides insights into neutrophil development regulation. Communications biology, 3(1), 1-12. (IF = 6.268)
10. Chen L#, Yang R#, et al. Chen L*. 2020. Paired rRNA-depleted and polyA-selected RNA sequencing data and supporting multi-omics data from human T cells. Scientific Data 7(1):376. (IF = 6.444)
11.Chen L#, Bing G#, Casale F P# et al. 2016. Genetic drivers of epigenetic and transcriptional. variation in human immune cells. Cell 167, 1398–1414. (IF = 41.582)
12.Chen L#, Kostadima M#, Martens JH# et al. 2014. Transcriptional diversity during lineage commitment of human blood progenitors. Science 345(6204): 1251033. (IF = 47.728)
13. Chen L#, Bush SJ#, Tovar-Corona JM et al. 2014. Correcting for Differential Transcript Coverage Reveals a Strong Relationship between Alternative Splicing and Organism Complexity. Molecular biology and evolution 31(6): 1402-1413. (IF = 16.24)
14.Chen L#, Tovar-Corona JM, Urrutia AO. 2012. Alternative splicing: a potential source of functional innovation in the eukaryotic genome. International journal of evolutionary biology. 2012:596274.
15.Chen L#, Tovar-Corona JM, Urrutia AO. 2011. Increased levels of noisy splicing in cancers, but not for oncogene-derived transcripts. Human molecular genetics 20(22):4422-4429. (IF = 6.15)
16.Chen L#, Zhang Q, Wang W, Wang Y. 2010. Spatiotemporal ex-x-pression of Pax genes in amphioxus: insights into Pax-related organogenesis and evolution. Science China Life Sciences 53(8):1031-1040. (IF = 6.038)
Co-author papers
1. Feifei Na, Xiangyu Pan, Jingyao Chen, (including Chen L) & Chen C. KMT2C deficiency promotes small cell lung cancer me-x-tastasis through DNMT3A-mediated epigenetic reprogramming. Nature Cancer 1-15
2. Hong, W., Yang, J., Zou, J., Bi, Z., He, C., Lei, H., ... & Wei, X. Histones released by NETosis enhance the infectivity of SARS-CoV-2 by bridging the spike protein subunit 2 and sialic acid on host cells. Cellular & molecular immunology, 1-11.
3. Chen M, Chen X, Li S, (including Chen L) ... & Yu Liu. 2021. An Epigenetic Mechanism Underlying Chromosome 17p Deletion-Driven Tumorigenesis. Cancer Discovery 11(1):194-207.
4. Lin C, Jiang M, Liu L, (including Chen L) ... & Rongqin Ke. 2021. Imaging of individual transcripts by amplification-based single-molecule fluorescence in situ hybridization. New Biotechnology 61:116-123.
5. Watt S, Vasquez L, Walter K, (including Chen L) ... & Nicole Soranzo. 2021. Genetic perturbation of PU.1 binding and chromatin looping at neutrophil enhancers associates with autoimmune disease. Nature communications 12(1):2298.
6. Han Z, Zhang W, Ning W, (including Chen L) ... & Da Jia. 2021. Model-based analysis uncovers mutations altering autophagy selectivity in human cancer. Nature Communications 12(1):3258.
7. Zhao Y, Lin C, Wu P, (including Chen L) ... & Rongqin Ke. 2020. Single Cell RNA ex-x-pression Analysis Using Flow Cytometry Based on Specific Probe Ligation and Rolling Circle Amplification. ACS sensors 5(10):3031-3036.
8. Yang, J., Wang, W., Chen, Z., (including Chen L) ... & Wei, X. 2020. A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity. Nature, 586(7830), 572-577.
9. Luo, W., Tian, P., Wang, Y., Xu, H., Chen, L., Tang, C., ... & Li, W. 2018. Characteristics of genomic alterations of lung adenocarcinoma in young never‐smokers. International journal of cancer 143(7), 1696-1705.
10. Cheung, W. A., Shao, X., Morin, A., (including Chen L) ... & Grundberg, E. 2017. Functional variation in allelic methylomes underscores a strong genetic contribution and reveals novel epigenetic alterations in the human epigenome. Genome biology 18(1), 1-21.
11. Ecker, S., Chen, L., Pancaldi, V., Bagger, F. O., Fernández, J. M., de Santa Pau, E. C., ... & Paul, D. S. 2017. Genome-wide analysis of differential transcriptional and epigenetic variability across human immune cell types. Genome biology 18(1), 1-17.
12. Bush, S. J., Chen, L., Tovar-Corona, J. M., & Urrutia, A. O. 2017. Alternative splicing and the evolution of phenotypic novelty. Philosophical Transactions of the Royal Society B: Biological Sciences 372(1713), 20150474.
13. Astle WJ, Elding H, Jiang T, (including Chen L) ... & Nicole Soranzo. 2016. The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. Cell 167, 1415-1429.
14. Iotchkova V, Huang J, Morris JA, (including Chen L) ... & Nicole Soranzo. 2016. Discovery and refinement of genetic loci associated with cardiome-x-tabolic risk using dense imputation maps. Nature genetics 48(11): 1303-1312
15. Vasquez LJ, Mann AL, Chen L, Soranzo N. 2016. From GWAS to function: lessons from blood cells. ISBT Science Series11(Suppl 1):211-219.
16. Polfus LM, Khajuria RK, Schick UM, (including Chen L) ... & Vijay G Sankaran. 2016. Whole-Exome Sequencing Identifies Loci Associated with Blood Cell Traits and Reveals a Role for Alternative GFI1B Splice Variants in Human Hematopoiesis. The American Journal of Human Genetics 99(3):785.
17. UK10K Consortium, Walter K, Min JL, (including Chen L) ... & Nicole Soranzo. 2015. The UK10K project: rare variants in health and disease. Nature 526 (7571): 82-90.
18. Tovar-Corona JM, Castillo-Morales A, Chen L... & Araxi O Urrutia. 2015. Alternative Splice in Alternative Lice. Molecular biology and evolution 32(10):2749-2759.
19. Bush SJ, Castillo-Morales A, Tovar-Corona JM, (including Chen L) ... & Araxi O Urrutia. 2014. Presence-absence variation in A. thaliana is primarily associated with genomic signatures consistent with relaxed selective constraints. Molecular biology and evolution 31(1):59-69.
20. Shin SY, Fauman EB, Petersen AK, (including Chen L) ... & Nicole Soranzo. 2014. An atlas of genetic influences on human blood me-x-tabolites. Nature genetics 46(6): 543-550.
21. Timpson NJ, Walter K, Min JL, (including Chen L) ... & Nicole Soranzo. 2014. A rare variant in APOC3 is associated with plasma triglyceride and VLDL levels in Europeans. Nature communications 5:4871.
22. Wu X, Tronholm A, Cáceres EF, (including Chen L) ... & Laurence D Hurst. 2013. Evidence for deep phylogenetic conservation of exonic splice-related constraints: splice-related skews at exonic ends in the brown alga Ectocarpus are common and resemble those seen in humans. Genome biology and evolution 5(9):1731-1745.
