职称：研究员
2. 学历：博士
3. 研究方向：实验室运用神经生物学和细胞生物学等多种技术手段, 研究中枢/外周神经系统损伤后轴突再生及髓鞘修复的分子机制；多发性硬化症的发病机理和治疗策略
4. 邮件：xuelian_he2021@scu.edu.cn 或 hj1070803@163.com
5. 个人简历：
2021年至今尊龙凯时华西第二尊龙凯时，PI
2017年至2020年哈佛医学院波士顿儿童尊龙凯时，博士后
2013年至2017年美国辛辛那提儿童尊龙凯时，博士后
2013年美国西南医学研究中心，博士后
2011年至2014年尊龙凯时，博士
负责人在过去的十几年间，在神经发育、神经系统肿瘤、神经损伤后的再生修复等多个领域接收了系统性训练。截至2021年，申请并受理美国专利3项，以第一作者/通讯作者（包括共同）在Nature, Nature Medicine（2篇）, Cancer Cell, Neuron（2篇）等国际高影响力期刊发表论文。
6. 代表性论文
(1). Yi Li#, XuelianHe#, Riki Kawaguchi#, Yu Zhang,Qing Wang, Aboozar Monavarfeshani, Zhiyun Yang, Bo Chen, Zhongju Shi, HuyanMeng, Songlin Zhou, Junjie Zhu, Anne Jacobi, Vivek Swarup, Phillip G. Popovich,Daniel H. Geschwind & Zhigang He. “Microglia-organized scar- freespinal cord repair in neonatal mice”. Nature (2020)Nov;587(7835):613-618. (Co-first author)
(2). Jing Wang#, Xuelian He#, Huyan Meng, Yi Li, Philip Dmitriev, Feng Tian, Jessica C Page, QRichard Lu, Zhigang He. “Robust myelination of regenerated axons induced bycombined manipulations of GPR17 and microglia”. Neuron (2020), Dec9;108(5):876-886.e4. (Co-first author)
(3).XuelianHe, Liguo Zhang, Luis F Queme,Xuezhao Liu, Andrew Lu, Ronald R Waclaw, Andres Buonanno, Joshua B Rubin, MeiXin, Klaus-Armin Nave, Bruce D Trapp, Michael P Jankowski & Q Richard Lu “Ahistone deacetylase 3– dependent pathway delimits peripheral myelin growth andfunctional regeneration”. NatureMedicine (2018) Mar;24(3):338-351.
(4).XuelianHe, Liguo Zhang, Ying Chen, MarcRemke, David ShihVijay Ramaswamy, Tom Hu, Fan Wang, Wenhao Zhou, Dennis K.Burns, Se Hoon Kim, Marcel Kool, Stefan M. Pfister, Lee S. Weinstein, Scott L.Pomeroy, Richard J. Gilbertson, Joshua B. Rubin, Yiping Hou, RobertWechsler- Reya, Michael D. Taylor and Q. Richard Lu. “The G-protein AlphaSubunit Gsα Is A Tumor Suppressor in Sonic Hedgehog-drivenMedulloblastoma”, NatureMedicine, (2014) Sep;20(9):1035-42. (Coverhighlight)
(5).Liguo Zhang#, Xuelian He*#, Xuezhao Liu, Feng Zhang, Lei F. Huang, Andrew S. Potter, LingliXu, Wenhao Zhou, Tao Zheng, Zaili Luo, Kalen Berry, Allison Pribnow, StephanieM. Smith, Christine Fuller, Blaise V. Jones, Maryam Fouladi, Rachid Drissi,Zengjie Yang,W. Clay Gustafson, Marc Remke, Scott Pomeroy, Emily J. Girard,James M. Olson, A. Sorana Morrissy, Maria C. Vladoiu, Jiao Zhang, Weidong Tian,Mei Xin, Michael D. Taylor,Steven Potter, Martine F. Roussel, William A.Weiss,and Q. Richard Lu*. “Single-Cell Transcriptomics in MedulloblastomaReveals Tumor-Initiating Progenitors and Oncogenic Cascades duringTumorigenesis and Relapse”. Cancer cell (2019),Sep 16;36(3):302-318.e7. (#Co-first authorand *Co-corresponding author) (Cover story)
(6).Xianghui Zhao#, Xuelian He#, Xiaolei Han#, Yang Yu, Feng Ye, Ying Chen, ThaoNguyen Hoang, Xiaomei Xu, Mei Xin, Fan Wang, Bruce Appel, and Q. Richard Lu “MicroRNA-mediatedcontrol of oligodendrocyte differentiation”. Neuron (2010) 65, 612-626 (Co-firstauthor)
(7).Liguo Zhang#, Xuelian He#, Lei Liu, Minqing Jiang, Chuntao Zhao, Haibo Wang, Danyang He,Tao Zheng, Xianyao Zhou, Aishlin Hassan, Zhixing Ma, Mei Xin, Zheng Sun,Mitchell A. Lazar, Steven A. Goldman, Eric N. Olson, and Q. Richard Lu. “Hdac3Interaction with p300 Histone Acetyltransferase Regulates the Oligodendrocyteand Astrocyte Lineage Fate Switch”, Developmental Cell, (2016). Volume 36, Issue 3, p316–330, 8 February.(Co-first author)
(8).XuelianHe, Yang Yu, RajeshwarAwatramani, Q. Richard Lu. “Unwrapping myelination by microRNAs”. Neuroscientist. Feb;18(1):45-55. Epub 2011 May 2. (2012)
(9).XuelianHe & Q. Richard Lu.“G-Protein Gαs controls medulloblastoma initiation by suppressingsonic hedgehog signaling”, Molecular & Cellular Oncology, 2015, 2:2, e975070
(10).Yang Yu, Ying Chen, Bongwoo Kim, Haibo Wang, ChuntaoZhao, Xuelian He, Lei Liu, Wei Liu, Lai Man N.Wu, Meng Mao, Jonah R. Chan, Jiang Wu, and Q. Richard Lu. “Olig2 TargetsChromatin Remodelers To Enhancers To Initiate Oligodendrocyte Differentiation”. Cell 152: 248–261(2013)
